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Shivakumaraswamy, Santosh ; Kumar, Sanjeev ; Bellur, Asutosh ; Polisetty, Satya Dev ; Balaram, Hemalatha (2022) Mechanistic Insights into the Functioning of a Two-Subunit GMP Synthetase, an Allosterically Regulated, Ammonia Channeling Enzyme Biochemistry, 61 (18). pp. 1988-2006. ISSN 0006-2960

Dongre, Aparna Vilas ; Das, Sudip ; Bellur, Asutosh ; Kumar, Sanjeev ; Chandrashekarmath, Anusha ; Karmakar, Tarak ; Balaram, Padmanabhan ; Balasubramanian, Sundaram ; Balaram, Hemalatha (2021) Structural basis for the hyperthermostability of an archaeal enzyme induced by succinimide formation Biophysical Journal, 120 (17). pp. 3732-3746. ISSN 0006-3495

Carrique, Loïc ; Ballut, Lionel ; Shukla, Arpit ; Varma, Neelakshi ; Ravi, Resmi ; Violot, Sébastien ; Srinivasan, Bharath ; Ganeshappa, Umesh Tippagondanahalli ; Kulkarni, Sonia ; Balaram, Hemalatha ; Aghajari, Nushin (2020) Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase Nature Communications, 11 (1). ISSN 2041-1723

Sruthi, Cheloor Kovilakam ; Balaram, Hemalatha ; Prakash, Meher K. (2020) Toward Developing Intuitive Rules for Protein Variant Effect Prediction Using Deep Mutational Scanning Data ACS Omega, 5 (46). pp. 29667-29677. ISSN 2470-1343

Nagappa, Lakshmeesha Kempaiah ; Singh, Dipti ; Dey, Sandeep ; Kumar, Kota Arun ; Balaram, Hemalatha (2019) Biochemical and physiological investigations on adenosine 5ʹ monophosphate deaminase fromPlasmodium spp. Molecular Microbiology, 112 (2). pp. 699-717. ISSN 0950-382X

Nagappa, Lakshmeesha Kempaiah ; Satha, Pardhasaradhi ; Govindaraju, Thimmaiah ; Balaram, Hemalatha (2019) Correction: Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in Plasmodium berghei. Journal of Biological Chemistry, 294 (44). p. 16479. ISSN 0021-9258

Nagappa, Lakshmeesha Kempaiah ; Balasubramanian, Sundaram ; Balaram, Hemalatha (2019) How a purine salvage enzyme singles out the right base Journal of Biological Chemistry, 294 (32). pp. 11992-11993. ISSN 0021-9258

Kempaiah Nagappa, Lakshmeesha ; Satha, Pardhasaradhi ; Govindaraju, Thimmaiah ; Balaram, Hemalatha (2019) Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in Plasmodium berghei Journal of Biological Chemistry, 294 (13). pp. 4997-5007. ISSN 0021-9258

Jayaraman, Vijay ; Suryavanshi, Arpitha ; Kalale, Pavithra ; Kunala, Jyothirmai ; Balaram, Hemalatha (2018) Biochemical characterization and essentiality of fumarate hydratase Journal of Biological Chemistry, 293 (16). pp. 5878-5894. ISSN 0021-9258

Perinbam, Kumar ; Balaram, Hemalatha ; Guru Row, Tayur N. ; Gopal, Balasubramanian (2017) Probing the influence of non-covalent contact networks identified by charge density analysis on the oxidoreductase BacC Protein Engineering, Design and Selection, 30 (3). pp. 265-272. ISSN 1741-0126

Pareek, Vidhi ; Samanta, Moumita ; Joshi, Niranjan V ; Balaram, Hemalatha ; Murthy, Mathur R. N. ; Balaram, Padmanabhan (2016) Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme ChemBioChem, 17 (7). pp. 620-629. ISSN 1439-4227

Karnawat, Vishakha ; Mehrotra, Sonali ; Balaram, Hemalatha ; Puranik, Mrinalini (2016) Exquisite Modulation of the Active Site of Methanocaldococcus jannaschii Adenylosuccinate Synthetase in Forward Reaction Complexes Biochemistry, 55 (17). pp. 2491-2499. ISSN 0006-2960

Karmakar, Tarak ; Roy, Sourav ; Balaram, Hemalatha ; Prakash, Meher K. ; Balasubramanian, Sundaram (2016) Product Release Pathways in Human and Plasmodium falciparum Phosphoribosyltransferase Journal of Chemical Information and Modeling, 56 (8). pp. 1528-1538. ISSN 1549-9596

Roy, Sourav ; Karmakar, Tarak ; Nagappa, Lakshmeesha K. ; Prahlada Rao, Vasudeva S. ; Balasubramanian, Sundaram ; Balaram, Hemalatha (2016) Role of W181 in modulating kinetic properties ofPlasmodium falciparumhypoxanthine guanine xanthine phosphoribosyltransferase Proteins: Structure, Function, and Bioinformatics, 84 (11). pp. 1658-1669. ISSN 0887-3585

Karmakar, Tarak ; Roy, Sourav ; Balaram, Hemalatha ; Balasubramanian, Sundaram (2016) Structural and dynamical correlations in PfHGXPRT oligomers: A molecular dynamics simulation study Journal of Biomolecular Structure and Dynamics, 34 (7). pp. 1590-1605. ISSN 0739-1102

Kumar, Sanjeev ; Prakash, Sunita ; Gupta, Kallol ; Dongre, Aparna ; Balaram, Padmanabhan ; Balaram, Hemalatha (2016) Unexpected functional implication of a stable succinimide in the structural stability of Methanocaldococcus jannaschii glutaminase Nature Communications, 7 (1). ISSN 2041-1723

Ballut, Lionel ; Violot, Sébastien ; Shivakumaraswamy, Santosh ; Thota, Lakshmi Prasoona ; Sathya, Manu ; Kunala, Jyothirmai ; Dijkstra, Bauke W. ; Terreux, Raphaël ; Haser, Richard ; Balaram, Hemalatha ; Aghajari, Nushin (2015) Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation Nature Communications, 6 (1). ISSN 2041-1723

Karnawat, Vishakha ; Gogia, Spriha ; Balaram, Hemalatha ; Puranik, Mrinalini (2015) Differential Distortion of Purine Substrates by Human andPlasmodium falciparumHypoxanthine-Guanine Phosphoribosyltransferase to Catalyse the Formation of Mononucleotides ChemPhysChem, 16 (10). pp. 2172-2181. ISSN 1439-4235

Roy, Sourav ; Nagappa, Lakshmeesha K. ; Prahladarao, Vasudeva S. ; Balaram, Hemalatha (2015) Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase Molecular and Biochemical Parasitology, 204 (2). pp. 111-120. ISSN 0166-6851

Srinivasan, Bharath ; Kempaiah Nagappa, Lakshmeesha ; Shukla, Arpit ; Balaram, Hemalatha (2015) Prediction of substrate specificity and preliminary kinetic characterization of the hypothetical protein PVX_123945 from Plasmodium vivax Experimental Parasitology, 151-15 . pp. 56-63. ISSN 0014-4894

Bandyopadhyay, Debarati ; Murthy, Mathur R. N. ; Balaram, Hemalatha ; Balaram, Padmanabhan (2015) Probing the role of highly conserved residues in triosephosphate isomerase - analysis of site specific mutants at positions 64 and 75 in thePlasmodialenzyme FEBS Journal, 282 (20). pp. 3863-3882. ISSN 1742-464X

Roy, Sourav ; Karmakar, Tarak ; S. Prahlada Rao, Vasudeva ; K. Nagappa, Lakshmeesha ; Balasubramanian, Sundaram ; Balaram, Hemalatha (2015) Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase Molecular BioSystems, 11 (5). pp. 1410-1424. ISSN 1742-206X

Williams, Sunanda Margrett ; Chandran, Anu V. ; Vijayabaskar, Mahalingam S. ; Roy, Sourav ; Balaram, Hemalatha ; Vishveshwara, Saraswathi ; Vijayan, Mamannamana ; Chatterji, Dipankar (2014) A Histidine Aspartate Ionic Lock Gates the Iron Passage in Miniferritins from Mycobacterium smegmatis Journal of Biological Chemistry, 289 (16). pp. 11042-11058. ISSN 0021-9258

Banerjee, Sanchari ; Agrawal, Monika J. ; Mishra, Diptimayee ; Sharan, Siddharth ; Balaram, Hemalatha ; Savithri, Handanhal S. ; Murthy, Mathur R. N. (2014) Structural and kinetic studies on adenylosuccinate lyase fromMycobacterium smegmatisandMycobacterium tuberculosisprovide new insights on the catalytic residues of the enzyme FEBS Journal, 281 (6). pp. 1642-1658. ISSN 1742-464X

Ali, Rustam ; Kumar, Sanjeev ; Balaram, Hemalatha ; Sarma, Siddhartha P. (2013) Solution Nuclear Magnetic Resonance Structure of the GATase Subunit and Structural Basis of the Interaction between GATase and ATPPase Subunits in a two-subunit-type GMPS from Methanocaldococcus jannaschii Biochemistry, 52 (25). pp. 4308-4323. ISSN 0006-2960

Mehrotra, Sonali ; Ningappa, Mylarappa B. ; Raman, Jayalakshmi ; Anand, Ranjith P. ; Balaram, Hemalatha (2012) Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1824 (4). pp. 589-597. ISSN 1570-9639

Jayaraman, Vijay ; Bulusu, Vinay ; Balaram, Hemalatha (2012) Crosstalk between purine nucleotide metabolism and mitochondrial pathways in Plasmodium falciparum Current Science (Bangalore), 102 (5). pp. 757-766. ISSN 0011-3891

Ali, Rustam ; Kumar, Sanjeev ; Balaram, Hemalatha ; Sarma, Siddhartha P. (2012) ⁽¹⁾H, ⁽¹³⁾C, ⁽¹⁵⁾N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii Biomolecular NMR Assignments, 6 (2). pp. 193-196. ISSN 1874-270X

Chakrabarty, S. P. ; Balaram, H. ; Chandrasekaran, S. (2011) Sirtuins: multifaceted drug targets Current Molecular Medicine, 11 (9). pp. 709-718. ISSN 1566-5240

Bhat, Javaid Y. ; Venkatachala, Roopa ; Balaram, Hemalatha (2011) Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase FEBS Journal, 278 (19). pp. 3756-3768. ISSN 1742-464X

Samanta, Moumita ; Murthy, M. R. N. ; Balaram, Hemalatha ; Balaram, Padmanabhan (2011) Revisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residue ChemBioChem, 12 (12). pp. 1886-1896. ISSN 1439-4227

Banerjee, Mousumi ; Gupta, Kallol ; Balaram, Hemalatha ; Balaram, Padmanabhan (2011) Mass spectrometric identification of an intramolecular disulfide bond in thermally inactivated triosephosphate isomerase from a thermophilic organism Methanocaldococcus jannaschii Rapid Communications in Mass Spectrometry, 25 (14). pp. 1915-1923. ISSN 0951-4198

Samanta, Moumita ; Banerjee, Mousumi ; Murthy, R. N. Mathur ; Balaram, Hemalatha ; Balaram, Padmanabhan (2011) Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis - distal effects on dimer stability FEBS Journal, 278 (11). pp. 1932-1943. ISSN 1742-464X

Gogia, Spriha ; Balaram, Hemalatha ; Puranik, Mrinalini (2011) Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pK_a of bound xanthosine monophosphate Biochemistry, 50 (19). pp. 4184-4193. ISSN 0006-2960

Bulusu, Vinay ; Thakur, Suman S. ; Venkatachala, Roopa ; Balaram, Hemalatha (2011) Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) Molecular and Biochemical Parasitology, 177 (1). pp. 1-11. ISSN 0166-6851

Vemparala, Satyavani ; Mehrotra, Sonali ; Balaram, Hemalatha (2011) Role of loop dynamics in thermal stability of mesophilic and thermophilic adenylosuccinate synthetase: a molecular dynamics and normal mode analysis study Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1814 (5). pp. 630-637. ISSN 1570-9639

Bhat, Javaid Yousuf ; Venkatachala, Roopa ; Singh, Kavita ; Gupta, Kallol ; Sarma, Siddhartha P. ; Balaram, Hemalatha (2011) Ammonia channeling in Plasmodium falciparum GMP synthetase: investigation by NMR spectroscopy and biochemical assays Biochemistry, 50 (16). pp. 3346-3356. ISSN 0006-2960

Bulusu, Vinay ; Jayaraman, Vijay ; Balaram, Hemalatha (2011) Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum Journal of Biological Chemistry, 286 (11). pp. 9236-9245. ISSN 0021-9258

Banerjee, Mousumi ; Balaram, Hemalatha ; Joshi, N. V. ; Balaram, P. (2011) Engineered dimer interface mutants of triosephosphate isomerase: the role of inter-subunit interactions in enzyme function and stability Protein Engineering Design and Selection, 24 (5). pp. 463-472. ISSN 1741-0126

Mehrotra, Sonali ; Mylarappa, B. N. ; Iyengar, Prathima ; Balaram, Hemalatha (2010) Studies on active site mutants of P-falciparum adenylosuccinate synthetase: Insights into enzyme catalysis and activation Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1804 (10). pp. 1996-2002. ISSN 1570-9639

Chakrabarty, Subhra Prakash ; Balaram, Hemalatha (2010) Reversible binding of zinc in Plasmodium falciparum Sir2: Structure and activity of the apoenzyme Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1804 (9). pp. 1743-1750. ISSN 1570-9639

Mehrotra, Sonali ; Bopanna, Monnanda P. ; Bulusu, Vinay ; Balaram, Hemalatha (2010) Adenine metabolism in Plasmodium falciparum Experimental Parasitology, 125 (2). pp. 147-151. ISSN 0014-4894

Chakrabarty, Subhra Prakash ; Ramapanicker, Ramesh ; Mishra, Roli ; Chandrasekaran, Srinivasan ; Balaram, Hemalatha (2009) Development and characterization of lysine based tripeptide analogues as inhibitors of Sir2 activity Bioorganic & Medicinal Chemistry, 17 (23). pp. 8060-8072. ISSN 0968-0896

Gayathri, P. ; Banerjee, Mousumi ; Vijayalakshmi, A. ; Balaram, Hemalatha ; Balaram, P. ; Murthy, M. R. N. (2009) Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site Acta Crystallographica Section D: Biological Crystallography, 65 (8). pp. 847-857. ISSN 0907-4449

Banerjee, Mousumi ; Balaram, Hemalatha ; Balaram, Padmanabhan (2009) Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase: the role of conserved residues and complementary mutations FEBS Journal, 276 (15). pp. 4169-4183. ISSN 1742-464X

Bulusu, Vinay ; Srinivasan, Bharath ; Bopanna, Monnanda Ponnappa ; Balaram, Hemalatha (2009) Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1794 (4). pp. 642-654. ISSN 1570-9639

Gayathri, P. ; Subbayya, I. N. Sujay ; Ashok, Chethan S. ; Selvi, T. Senthamizh ; Balaram, Hemalatha ; Murthy, M. R. N. (2008) Crystal structure of a chimera of human and plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization Proteins: Structure, Function, and Bioinformatics, 73 (4). 1010 - 1020. ISSN 0887-3585

Mehrotra, Sonali ; Balaram, Hemalatha (2008) Methanocaldococcus jannaschii adenylosuccinate synthetase: Studies on temperature dependence of catalytic activity and structural stability Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1784 (12). pp. 2019-2028. ISSN 1570-9639

Datta, K. K. R. ; Srinivasan, B. ; Balaram, H. ; Eswaramoorthy, M. (2008) Synthesis of agarose-metal/semiconductor nanoparticles having superior bacteriocidal activity and their simple conversion to metal-carbon composites Journal of Chemical Sciences, 120 (6). pp. 579-586. ISSN 0253-4134

Chakrabarty, Subhra Prakash ; Saikumari, Yegnisettipalli Krishnaiah ; Bopanna, Monnanda P. ; Balaram, Hemalatha (2008) Biochemical characterization of plasmodium falciparum Sir2, a NAD⁺-dependent deacetylase Molecular and Biochemical Parasitology, 158 (2). pp. 139-151. ISSN 0166-6851

Bhat, Javaid Yousuf ; Shastri, Brahmanaspati Ganapathi ; Balaram, Hemalatha (2008) Kinetic and biochemical characterization of Plasmodium falciparum GMP synthetase Biochemical Journal, 409 (1). pp. 263-273. ISSN 0264-6021

Gayathri, P. ; Balaram, Hemalatha ; Murthy, M. R. N. (2007) Structural biology of plasmodial proteins Current Opinion in Structural Biology, 17 (6). pp. 744-754. ISSN 0959-440X

Mehrotra, Sonali ; Balaram, Hemalatha (2007) Kinetic characterization of adenylosuccinate synthetase from the thermophilic archaea methanocaldococcus jannaschii Biochemistry, 46 (44). pp. 12821-12832. ISSN 0006-2960

Kalra, Sukirti ; Paul, Manash K. ; Balaram, Hemalatha ; Mukhopadhyay, Anup Kumar (2007) Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase-an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line Journal of Chromatography: B, 850 (1-2). pp. 7-14. ISSN 1570-0232

Gayathri, P. ; Banerjee, M. ; Vijayalakshmi, A. ; Azeez, S. ; Balaram, H. ; Balaram, P. ; Murthy, M. R. N. (2007) Structure of triosephosphate isomerase (TIM) from Methanocaldococcus jannaschii Acta Crystallographica Section D: Biological Crystallography, 63 (2). pp. 206-220. ISSN 0907-4449

Srinivasan, Bharath ; Balaram, Hemalatha (2007) ISN1 Nucleotidases and HAD Superfamily Protein Fold: In silico Sequence and Structure Analysis In Silico Biology, 7 (2). pp. 187-193. ISSN 1386-6338

Sabareesh, V. ; Ranganayaki, R. S. ; Raghothama, S. ; Bopanna, M. P. ; Balaram, Hemalatha ; Srinivasan, M. C. ; Balaram, P. (2007) Identification and Characterization of a Library of Microheterogeneous Cyclohexadepsipeptides from the Fungus Isaria Journal of Natural Products, 70 (5). pp. 715-729. ISSN 0163-3864

Raman, Jayalakshmi ; Ashok, Chethan S. ; Subbayya, Sujay I. N. ; Anand, Ranjith P. ; Selvi, Senthamizh T. ; Balaram, Hemalatha (2005) Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase-Stability studies on the product-activated enzyme FEBS Journal, 272 (8). pp. 1900-1911. ISSN 1742-464X

Raman, Jayalakshmi ; Mehrotra, Sonali ; Anand, Ranjith P. ; Balaram, Hemalatha (2004) Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase Molecular and Biochemical Parasitology, 138 (1). pp. 1-8. ISSN 0166-6851

Eaazhisai, K. ; Balaram, H. ; Balaram, P. ; Murthy, M. R. N. (2004) Structures of unliganded and inhibitor complexes of W168F, a loop6 hinge mutant of Plasmodium falciparum Triosephosphate Isomerase: observation of an intermediate position of loop6 Journal of Molecular Biology, 343 (3). pp. 671-684. ISSN 0022-2836

Raman, Jayalakshmi ; Sumathy, K. ; Anand, Ranjith P. ; Balaram, Hemalatha (2004) A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity Archives of Biochemistry and Biophysics, 427 (1). pp. 116-122. ISSN 0003-9861

Eaazhisai, K. ; Jayalakshmi, R. ; Gayathri, P. ; Anand, R. P. ; Sumathy, K. ; Balaram, H. ; Murthy, M. R. N. (2004) Crystal Structure of fully ligated adenylosuccinate synthetase from plasmodium falciparum Journal of Molecular Biology, 335 (5). pp. 1251-1264. ISSN 0022-2836

Raman, Jayalakshmi ; Balaram, Hemalatha (2004) Nucleotide metabolism in Plasmodium falciparum: recent developments Medicinal Chemistry Reviews - Online, 1 (4). pp. 465-473. ISSN 1567-2034

Parthasarathy, Sampathkumar ; Eaazhisai, Kandiah ; Balaram, Hemalatha ; Balaram, Padmanabhan ; Murthy, Mathur R. N. (2003) Structure of Plasmodium falciparum triose-phosphate isomerase-2-phosphoglycerate complex at 1.1-Å resolution Journal of Biological Chemistry, 270 . pp. 52461-52470. ISSN 0021-9258

Pattanaik, Priyaranjan ; Jain, Bimba ; Ravindra, Gudihal ; Gopi, Hosahudya N. ; Pal, Prajna P. ; Balaram, Hemalatha ; Balaram, Padmanabhan (2003) Stage-specific profiling of Plasmodium falciparum proteases using an internally quenched multispecificity protease substrate Biochemical and Biophysical Research Communications, 309 (4). pp. 974-979. ISSN 0006-291X

Gopi, Hosahudya N. ; Ravindra, Gudihal ; Pal, Prajna P. ; Pattanaik, Priyaranjan ; Balaram, Hemalatha ; Balaram, Padmanabhan (2003) Proteolytic stability of beta-peptide bonds probed using quenched fluorescent substrates incorporating a hemoglobin cleavage site FEBS Letters, 535 (1-3). pp. 175-178. ISSN 0014-5793

Gopi, Hosahudya N. ; Ravindra, Gudihal ; Pal, Prajna P. ; Pattanaik, Priyaranjan ; Balaram, Hemalatha ; Balaram, Padmanabhan (2003) Proteolytic stability of β-peptide bonds probed using quenched fluorescent substrates incorporating a hemoglobin cleavage site FEBS Letters, 535 (1). pp. 175-178. ISSN 0014-5793

Pattanaik, Priyaranjan ; Ravindra, Gudihal ; Sengupta, Chandana ; Maithal, Kapil ; Balaram, Padmanabhan ; Balaram, Hemalatha (2003) Unusual fluorescence of W168 in Plasmodium falciparum triosephosphate isomerase, probed by single-tryptophan mutants European Journal of Biochemistry, 270 (4). pp. 745-756. ISSN 0014-2956

Maithal, Kapil ; Ravindra, Gudihal ; Nagaraj, G. ; Singh, S. Kumar ; Balaram, Hemalatha ; Balaram, P. (2002) Subunit interface mutation disrupting an aromatic cluster in Plasmodium falciparum triosephosphate isomerase: effect on dimer stability Protein Engineering Design & Selection, 15 (7). pp. 575-584. ISSN 1741-0126

Sujay Subbayya, I. N. ; Balaram, H. (2002) A point mutation at the subunit interface of hypoxanthine-guanine-xanthine phosphoribosyltransferase impairs activity: role of oligomerization in catalysis. FEBS Letters, 521 (1-3). pp. 72-76. ISSN 0014-5793

Jayalakshmi, R. ; Sumathy, K. ; Balaram, Hemalatha (2002) Purification and characterization of recombinant Plasmodium falciparum adenylosuccinate synthetase expressed in escherichia coli Protein Expression and Purification, 25 (1). pp. 65-72. ISSN 1046-5928

Maithal, Kapil ; Ravindra, Gudihal ; Balaram, Hemalatha ; Balaram, Padmanabhan (2002) Inhibition of Plasmodium falciparum triose-phosphate isomerase by chemical modification of an interface cysteine- electrospray ionization mass spectrometric analysis of differential cysteine reactivities Journal of Biological Chemistry, 277 . pp. 25106-25114. ISSN 0021-9258

Pattanaik, Priyaranjan ; Raman, Jayalakshmi ; Balaram, Hemalatha (2002) Perspectives in drug design against malaria Current Topics in Medicinal Chemistry, 2 (5). pp. 483-505. ISSN 1568-0266

Parthasarathy, S. ; Ravindra, G. ; Balaram, Hemalatha ; Balaram, P. ; Murthy, M. R. N. (2002) Structure of the plasmodium falciparum triosephosphate isomerase-phosphoglycolate complex in two crystal forms: Characterization of catalytic loop open and closed conformations in the ligand-bound state Biochemistry, 41 (44). pp. 13178-13188. ISSN 0006-2960

Parthasarathy, S. ; Balaram, H. ; Balaram, P. ; Murthy, M. R. N. (2002) Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state Acta Crystallographica Section D: Biological Crystallography, D58 . pp. 1992-2000. ISSN 0907-4449

Shivashankar, K. ; Subbayya, Sujay I. N. ; Balaram, Hemalatha (2001) Development of a bacterial screen for novel hypoxanthine-guanine phosphoribosyltransferase substrates Journal of Molecular Microbiology and Biotechnology, 3 (4). pp. 557-562. ISSN 1464-1801

Singh, S. Kumar ; Maithal, Kapil ; Balaram, Hemalatha ; Balaram, P. (2001) Synthetic peptides as inactivators of multimeric enzymes: Inhibition of Plasmodium falciparum triosephosphate isomerase by interface peptides FEBS Letters, 501 (1). pp. 19-23. ISSN 0014-5793

Nagaraj, G. ; Uma, M. V. ; Shivayogi, M. S. ; Balaram, Hemalatha (2001) Antimalarial activities of peptide antibiotics isolated from fungi Antimicrobial Agents and Chemotherapy, 45 (1). pp. 145-149. ISSN 0066-4804

Nagaraj, G. ; Uma, M. V. ; Shivayogi, M. S. ; Balaram, Hemalatha (2001) Antimalarial activity of peptide antibiotics isolated from fungi Antimicrobial Agents and Chemotherapy, 45 (1). 145-149 . ISSN 0066-4804

Subbayya, I. N. Sujay ; Balaram, Hemalatha (2000) Evidence for multiple active states of plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase Biochemical and Biophysical Research Communications, 279 (2). pp. 433-437. ISSN 0006-291X

Sujay Subbayya, I. N. ; Sukumaran, Suja ; Shivashankar, K. ; Balaram, Hemalatha (2000) Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes Biochemical and Biophysical Research Communications, 272 (2). pp. 596-602. ISSN 0006-291X

Sumathy, K. ; Jayalakshmi, R. ; Shivayogi, M. S. ; Balaram, Hemalatha (2000) Cloning and characterization of the Plasmodium falciparum adenylosuccinate synthetase gene Current Science, 78 (5). pp. 610-615. ISSN 0011-3891

Ray, Soumya S. ; Balaram, Hemalatha ; Balaram, P. (1999) Unusual stability of a multiply nicked form of Plasmodium falciparum triosephosphate isomerase Chemistry & Biology, 6 (9). pp. 625-637. ISSN 1074-5521

Gokhale, Rajesh S. ; Ray, Soumya S. ; Balaram, Hemalatha ; Balaram, P. (1999) Unfolding of Plasmodium falciparum triosephosphate isomerase in urea and guanidinium chloride: evidence for a novel disulfide exchange reaction in a covalently cross-linked mutant Biochemistry, 38 (1). pp. 423-431. ISSN 0006-2960

Gopal, B. ; Ray, Soumya S. ; Gokhale, R. S. ; Balaram, H. ; Murthy, M. R. N. ; Balaram, P. (1998) Cavity-creating mutation at the dimer interface of Plasmodium falciparum triosephosphate isomerase: restoration of stability by disulfide cross-linking of subunits Biochemistry, 38 (1). pp. 478-486. ISSN 0006-2960

Velanker, Sameer S. ; Ray, Soumya S. ; Gokhale, Rajesh S. ; Suma S., ; Balaram, Hemalatha ; Balaram, P. ; Murthy, M. R. N. (1997) Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design Structure, 5 (6). pp. 751-761. ISSN 0969-2126

Sujay Subbayya, I. N. ; Ray, Sowmya S. ; Balaram, P. ; Balaram, Hemalatha (1997) Metabolic enzymes as potential drug targets in Plasmodium falciparum Indian Journal of Medical Research, 106 . pp. 79-94. ISSN 0971-5916

Ranie, Jamuna ; Kumar, Vidya P. ; Balaram, Hemalatha (1993) Cloning of the triosephosphate isomerase gene of Plasmodium falciparum and expression in Escherichia coli Molecular and Biochemical Parasitology, 61 (2). pp. 159-169. ISSN 0166-6851

Karle, Isabella L. ; Flippen-Anderson, Judith L. ; Uma, K. ; Balaram, Hemalatha ; Balaram, P. (1990) Peptide design: influence of a guest Aib-Pro segment on the stereochemistry of an Oligo-Val sequence - solution conformations and crystal structure of Boc-(Val)₂-Aib-Pro-(Val)₃-OMe Biopolymers, 29 (10-11). pp. 1433-1442. ISSN 0006-3525

Balaram, Hemalatha ; Uma, K. ; Balaram, P. (1990) Synthetic peptide models for protein secondary structures β-sheet formation in acyclic cystine peptides International Journal of Peptide and Protein Research, 35 (6). pp. 495-500. ISSN 0367-8377

Karle, I. L. ; Flippen-Anderson, J. L. ; Uma, K. ; Balaram, H. ; Balaram, P. (1989) Alpha-helix and mixed 3(10)/alpha-helix in cocrystallized conformers of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe PNAS, 86 (3). pp. 765-769. ISSN 0027-8424.

Moretto, V. ; Crisma, M. ; Bonora, G. M. ; Toniolo, C. ; Balaram, Hemalatha ; Balaram, P. (1989) Comparison of the effect of five guest residues on the β-sheet conformation of host (L-val)n oligopeptides Macromolecules, 22 (7). pp. 2939-2944. ISSN 0024-9297

Uma, K. ; Balaram, H. ; Raghothama, S. ; Balaram, P. (1988) Simultaneous observation of positive and negative nuclear overhauser effects in oligopeptides due to segmental motion Biochemical and Biophysical Research Communications, 151 (1). pp. 153-157. ISSN 0006-291X

Bardi, R. ; Piazzesi, A. M. ; Toniolo, C. ; Sen, N. ; Balaram, H. ; Balaram, P. (1988) Structures of pivaloyl-L-prolyl-N-methyl-D-phenylalaninamide and pivaloyl-L-prolyl-N-methyl-D-valinamide Acta Crystallographica Section C, 44 . pp. 1972-1976. ISSN 0108-2701

Balaram, Hemalatha ; Sukumar, M. ; Balaram, P. (1986) Stereochemistry of α-aminoisobutyric acid peptides in solution: conformations of decapeptides with a central triplet of contiguous L-amino acids Biopolymers, 25 (11). pp. 2209-2223. ISSN 0006-3525

Venkataram Prasad, B. V. ; Balaram, H. ; Balaram, P. (1984) Acyclic peptides as conformational models. Crystal structure of Boc-Aib-Leu-Pro-NHMe ±2H₂O International Journal of Peptide and Protein Research, 24 (2). pp. 135-140. ISSN 0367-8377

Crisma, M. ; Fasman, G. D. ; Balaram, H. ; Balaram, P. (1984) Peptide models for β-turns International Journal of Peptide and Protein Research, 23 (4). pp. 411-419. ISSN 0367-8377

Balaram, Hemalatha ; Venkataram Prasad, B. V. ; Balaram, P. (1983) Multiple conformational states of a Pro-Pro peptide. Solid-state and solution conformations of Boc-Aib-Pro-Pro-NHMe Journal of the American Chemical Society, 105 (12). pp. 4065-4071. ISSN 0002-7863

Rao, B. N. Narasinga ; Anil Kumar, ; Balaram, Hemalatha ; Ravi, A. ; Balaram, P. (1983) Nuclear Overhauser effects and circular dichroism as probes of β-turn conformations in acyclic and cyclic peptides with pro-X sequences Journal of the American Chemical Society, 105 (25). pp. 7423-7428. ISSN 0002-7863

Balaram, Hemalatha ; Venkataram Prasad, B. V. ; Balaram, P. (1982) Conformational transitions in a Pro-Pro peptide on dissolution of single crystals Biochemical and Biophysical Research Communications, 109 (3). pp. 825-831. ISSN 0006-291X

Venkataram Prasad, B. V. ; Balaram, Hemalatha ; Balaram, P. (1982) Type II β-turn conformation of pivaloyl-L-prolyl-α-aminoisobutyryl-N-methylamide: theoretical, spectroscopic, and X-ray studies Biopolymers, 21 (7). pp. 1261-1273. ISSN 0006-3525