Metabolic enzymes as potential drug targets in Plasmodium falciparum

Sujay Subbayya, I. N. ; Ray, Sowmya S. ; Balaram, P. ; Balaram, Hemalatha (1997) Metabolic enzymes as potential drug targets in Plasmodium falciparum Indian Journal of Medical Research, 106 . pp. 79-94. ISSN 0971-5916

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Plasmodium falciparum causes the most severe form of malaria that is fatal in many cases. Emergence of drug resistant strains of P. falciparum requires that new drug targets be-identified. This review considers in detail enzymes of the glycolytic pathway, purine salvage pathway, pyrimidine biosynthesis and proteases involved in catabolism of haemoglobin. Structural features of P. falciparum triosephosphate isomerase which could be exploited for parasite specific drug development have been highlighted. Utility of P. falciparum hypoxanthine-guanine-phosphoribosyltransferase, adenylosuccinate synthase, dihydroorotate dehydrogenase, thymidylate synthase-dihydrofolate reductase, cysteine and aspartic proteases have been elaborated in detail. The review also briefly touches upon other potential targets in P. falciparum.

Item Type:Article
Source:Copyright of this article belongs to Indian Council of Medical Research.
ID Code:91415
Deposited On:21 May 2012 12:50
Last Modified:13 Jul 2012 11:11

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