Non-standard amino acids in peptide design and protein engineering

Balaram, Padmanabhan (1992) Non-standard amino acids in peptide design and protein engineering Current Opinion in Structural Biology, 2 (6). pp. 845-851. ISSN 0959-440X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/095944...

Related URL: http://dx.doi.org/10.1016/0959-440X(92)90110-S

Abstract

The introduction of non-coded amino acids with well defined stereochemical and functional properties will greatly enhance the scope of protein design and engineering. The present state of methodologies for incorporation of non-coded residues into proteins is examined. The prospects for conformationally constrained amino acid residues are evaluated in the light of peptide structural studies. Templates for secondary-structure nucleation and recent experiences in the incorporation of novel residues into proteins are considered.

Item Type:Article
Source:Copyright of this article belongs to Current Opinion Journals.
ID Code:4135
Deposited On:13 Oct 2010 06:59
Last Modified:16 May 2016 14:49

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