Mehta, Goverdhan ; Mohal, Narinder (2000) A norbornyl route to azasugars: a new synthesis of deoxynojirimycin analogues Tetrahedron Letters, 41 (30). pp. 5741-5745. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/S0040-4039(00)00895-9
Abstract
A new synthesis of deoxynojirimycin (DNJ) analogues (galacto- and altrose configuration) has been achieved through a functionalized cyclopentene derivative crafted from the norbornyl system, employing double reductive amination as the key step. The new DNJ analogues have been evaluated against various glycosidases and found to be moderate to strong inhibitors.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Azasugars; Glycosidase Inhibitors; Osmylation; Reductive Amination |
| ID Code: | 29006 |
| Deposited On: | 18 Dec 2010 05:43 |
| Last Modified: | 17 May 2016 11:59 |
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