Aiyar, Jayashree ; Bhan, M. K. ; Bhandari, Nita ; Kumar, Ramesh ; Raj, Pushker ; Sazawal, Sunil (1990) Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea Journal of Infectious Diseases, 162 (6). pp. 1383-1384. ISSN 0022-1899
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Official URL: http://jid.oxfordjournals.org/content/162/6/1383
Related URL: http://dx.doi.org/10.1093/infdis/162.6.1383
Abstract
The reliability of saliva as an indicator of rotavirus infection was assessed among 15 infants (3-12 months) with rotaviral and 15 with nonrotaviral diarrhea. Paired salivary samples collected during acute and convalescent phases were tested for rotavirus-specific IgA and IgM by an ELISA. The sensitivity of IgA or IgM alone to predict infection was 53.3% and 46.6%, respectively; used in conjunction, the sensitivity rose to 80%. It seems that infants with rotaviral diarrhea mount mucosal antibody responses as reflected in their saliva; possibly salivary antibodies could be used to evaluate vaccine "take" in rotavirus vaccine trials.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Oxford University Press. |
| ID Code: | 99921 |
| Deposited On: | 28 Nov 2016 10:27 |
| Last Modified: | 28 Nov 2016 10:29 |
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