Maddur, Mohan S. ; Vani, Janakiraman ; Dimitrov, Jordan D. ; Balaji, Kithiganahalli Narayanaswamy ; Lacroix-Desmazes, Sebastien ; Kaveri, Srini V. ; Bayry, Jagadeesh (2010) Dendritic cells in autoimmune diseases The Open Arthritis Journal, 3 . pp. 1-7. ISSN 1876-5394
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Official URL: http://benthamopen.com/ABSTRACT/TOARTHJ-3-1
Related URL: http://dx.doi.org/10.2174/1876539401003010001
Abstract
Dendritic cells (DCs) are professional antigen presenting cells, which play a crucial role both in maintaining immune tolerance and in inducing adaptive immune responses. Therefore, DCs are the most sought in inciting autoimmunity and its sustenance to autoimmune diseases. The emerging knowledge of the importance of DCs, DC-derived cytokines, and intracellular signal transduction pathways in mediating autoimmune diseases and in creating an inflammatory environment provides a rationale for pursuing strategies to block these inflammatory pathways for therapeutic purposes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Open. |
| Keywords: | Dendritic cells, Autoimmunity, Rheumatology, Rheumatoid Arthritis; Lupus; Kawasaki Disease; T Cells; Cytokines; Co-stimulation |
| ID Code: | 99735 |
| Deposited On: | 26 Nov 2016 11:52 |
| Last Modified: | 26 Nov 2016 11:52 |
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