Baral, Abhishek ; Roy, Subhasish ; Dehsorkhi, Ashkan ; Hamley, Ian W. ; Mohapatra, Saswat ; Ghosh, Surajit ; Banerjee, Arindam (2014) Assembly of an injectable noncytotoxic peptide-based hydrogelator for sustained release of drugs Langmuir, 30 (3). pp. 929-936. ISSN 0743-7463
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Official URL: http://pubs.acs.org/doi/abs/10.1021/la4043638
Related URL: http://dx.doi.org/10.1021/la4043638
Abstract
A new synthetic tripeptide-based hydrogel has been discovered at physiological pH and temperature. This hydrogel has been thoroughly characterized using different techniques including field emission scanning electron microscopic (FE-SEM) and high-resolution transmission electron microscopic (HR-TEM) imaging, small- and wide-angle X-ray diffraction analyses, FT-IR, circular dichroism, and rheometric analyses. Moreover, this gel exhibits thixotropy and injectability. This hydrogel has been used for entrapment and sustained release of an antibiotic vancomycin and vitamin B12 at physiological pH and temperature for about 2 days. Interestingly, MTT assay of these gelator molecules shows almost 100% cell viability of this peptide gelator, indicating its noncytotoxicity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 99700 |
| Deposited On: | 28 Oct 2016 07:16 |
| Last Modified: | 28 Oct 2016 07:16 |
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