Tetrapeptide-based hydrogels: for encapsulation and slow release of an anticancer drug at physiological pH

Naskar, Jishu ; Palui, Goutam ; Banerjee, Arindam (2009) Tetrapeptide-based hydrogels: for encapsulation and slow release of an anticancer drug at physiological pH Journal of Physical Chemistry B, 113 (35). pp. 11787-11792. ISSN 1520-6106

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jp904251j

Related URL: http://dx.doi.org/10.1021/jp904251j

Abstract

Here, we report two synthetic oligopeptide-based, thermoreversible, pH-sensitive hydrogels. In gel phase, these self-assembling tetrapeptides form a long interconnected nanofibrilar network structure, as is evident from various microscopic techniques, including field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM). FTIR, circular dichroism, and wide angle X-ray diffraction (WAXD) favor an antiparallel beta-sheet structure of these gelators in the gel state. Finally, these hydrogels have been utilized for entrapment and slow release of an anticancer drug doxorubicin at physiological pH, promising their future application as a drug delivery vehicle.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:99638
Deposited On:03 Nov 2016 10:36
Last Modified:03 Nov 2016 10:36

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