Naskar, Jishu ; Drew, Michael G. B. ; Deb, Ishani ; Das, Sumantra ; Banerjee, Arindam (2008) A water-soluble tripeptide Aβ (9-11) forms amyloid-like fibrils and exhibits neurotoxicity Organic Letters, 10 (13). pp. 2625-2628. ISSN 1523-7060
Full text not available from this repository.
Official URL: http://pubs.acs.org/doi/abs/10.1021/ol8007217
Related URL: http://dx.doi.org/10.1021/ol8007217
Abstract
A water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides Aβ(9-11), upon self-association exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line. However, the tripeptides GFE and GWE, in which the centrally located tyrosine residue has been replaced by phenylalanine or tryptophan, fail to show amyloidogenic behavior and exhibit little or no neurotoxicity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 99624 |
| Deposited On: | 04 Nov 2016 12:12 |
| Last Modified: | 04 Nov 2016 12:12 |
Repository Staff Only: item control page
