A short water-soluble self-assembling peptide forms amyloid-like fibrils

Ray, Sudipta ; Das, Apurba K. ; Drew, Michael G. B. ; Banerjee, Arindam (2006) A short water-soluble self-assembling peptide forms amyloid-like fibrils Chemical Communications (40). pp. 4230-4232. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2006...

Related URL: http://dx.doi.org/10.1039/B607657B

Abstract

A water-soluble tripeptide Val–Ile–Ala (VIA) 1, bearing sequence identity with the C-terminal portion of the Alzheimer Aβ-peptide (Aβ40–42), self-assembles, in crystalline form, to produce an intermolecularly hydrogen bonded supramolecular β-sheet structure which self-associates to form straight, unbranched nanofibrils exhibiting amyloid-like behavior; in contrast, the synthetic tripeptide Ala–Val–Ile (AVI) 2 self-assembles to produce a β-sheet structure that forms branched nanofibrils which do not show any characteristic features of amyloid-like fibrils.

Item Type:Article
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