Maji, Samir Kumar ; Haldar, Debasish ; Drew, Michael G. B ; Banerjee, Arijit ; Das, Apurba Kumar ; Banerjee, Arindam (2004) Self-assembly of β-turn forming synthetic tripeptides into supramolecular β-sheets and amyloid-like fibrils in the solid state Tetrahedron, 60 (14). pp. 3251-3259. ISSN 0040-4020
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tet.2004.02.019
Abstract
We have described here the self-assembling properties of the synthetic tripeptides Boc-Ala(1)-Aib(2) -Val (3)-OMe 1, BocAla(l)-Aib(2)-Ile(3)-OMe 2 and Boc-Ala(l)-Gly(2)-Val(3)-OMe 3 (Aib=alpha-arnino isobutyric acid, beta-Ala=beta-alanine) which have distorted beta-turn conformations in their respective crystals. These turn-forming tripeptides self-assemble to form supramolecular beta-sheet structures through intermolecular hydrogen bonding and other noncovalent interactions. The scanning electron micrographs of these peptides revealed that these compounds form amyloid-like fibrils, the causative factor for many neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Prion-related encephalopathies.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Amyloid-Like Fibril; β-Turn; Supramolecular β-Sheet; Self-Assembling Peptides |
| ID Code: | 99526 |
| Deposited On: | 07 Nov 2016 11:15 |
| Last Modified: | 07 Nov 2016 11:15 |
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