Kelkar, Ashwin ; Thakur, Vivek ; Ramaswamy, Ramakrishna ; Deobagkar, Deepti (2009) Characterisation of inactivation domains and evolutionary strata in human X chromosome through Markov segmentation PLoS One, 4 (11). Article ID e7885, 8 pages. ISSN 1932-6203
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Official URL: http://journals.plos.org/plosone/article?id=10.137...
Related URL: http://dx.doi.org/10.1371/journal.pone.0007885
Abstract
Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure. The human X chromosome is known to have acquired DNA through distinct evolutionary events and is believed to be composed of five evolutionary strata. In addition, in female mammals all copies of X chromosome in excess of one are transcriptionally inactivated. The location of a gene is correlated with its ability to undergo inactivation, but correlations between evolutionary strata and inactivation domains are less clear. Our analysis provides an accurate estimate of the location of stratum boundaries and gives a high–resolution map of compositionally different regions on the X chromosome. This leads to the identification of a novel stratum, as well as segments wherein a group of genes either undergo inactivation or escape inactivation in toto. We identify oligomers that appear to be unique to inactivation domains alone.
Item Type: | Article |
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Source: | Copyright of this article belongs to Public Library of Science. |
ID Code: | 98840 |
Deposited On: | 20 May 2015 11:51 |
Last Modified: | 19 May 2016 10:45 |
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