Bhuyan, Jagannath ; Sarkar, Sabyasachi (2012) Nitrous-acid-mediated synthesis of iron-nitrosyl-porphyrin: pH-dependent release of nitric oxide Chemistry - An Asian Journal, 7 (11). pp. 2690-2695. ISSN 1861-4728
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/asia.20...
Related URL: http://dx.doi.org/10.1002/asia.201200518
Abstract
Two iron–nitrosyl–porphyrins, nitrosyl[meso-tetrakis(3,4,5-trimethoxyphenylporphyrin]iron(II) acetic acid solvate (3) and nitrosyl[meso-tetrakis(4-methoxyphenylporphyrin]iron(II) CH2Cl2 solvate (4), were synthesized in quantitative yield by using a modified procedure with nitrous acid, followed by oxygen-atom abstraction by triphenylphosphine under an argon atmosphere. These nitrosyl porphyrins are in the {FeNO}7 class. Under an argon atmosphere, these compounds are relatively stable over a broad range of pH values (4–8) but, under aerobic conditions, they release nitric oxide faster at high pH values than that at low pH values. The generated nitric-oxide-free iron(III)–porphyrin can be re-nitrosylated by using nitrous acid and triphenylphosphine. The rapid release of NO from these FeII complexes at high pH values seems to be similar to that in nitrophorin, a nitric-oxide-transport protein, which formally possesses FeIII. However, because the release of NO occurs from ferrous–nitrosyl–porphyrin under aerobic conditions, these compounds are more closely related to nitrobindin, a recently discovered heme protein.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons. |
Keywords: | EPR spectroscopy; Iron; Nitric Oxide; Porphyrinoids; X-ray Diffraction |
ID Code: | 98324 |
Deposited On: | 21 May 2014 09:57 |
Last Modified: | 21 May 2014 09:57 |
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