Mehrotra, Jyothi ; Misra, K. ; Mishra, Rakesh K. (1992) Photoinduced DNA strand scission by 1,8-naphthalimide-derived intercalators Current Science, 62 (10). pp. 693-695. ISSN 0011-3891
![]()
|
PDF
- Publisher Version
655kB |
Official URL: http://www.currentscience.ac.in/Downloads/article_...
Abstract
DNA cleavage by non-enzymatic chemical reagents has both basic and applied value. We report here photoinduced strand scission properties of novel DNA intercalators, 4-nitro (N-hexylamine)1,8-naphthalimide. The results indicate that the cleavage takes place via a free-radical mechanism and the efficiency of cleavage is unaltered over a long range pf pH and ionic strength. These intercalators, therefore, provide a probe for studying DNA conformation, conformational micro-heterogeneity, DNA-ligand interactions and have potential use in genome targeting.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to Current Science Association. |
ID Code: | 97051 |
Deposited On: | 22 Jan 2013 06:57 |
Last Modified: | 19 May 2016 09:16 |
Repository Staff Only: item control page