Ranganathan, Darshan ; Patel, Bhisma Kumar ; Mishra, Rakesh K. (1993) Design of a chemical nuclease model with (Lys)2Cu as the core motif Journal of the Chemical Society, Chemical Communications (4). pp. 337-339. ISSN 0022-4936
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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/1993...
Related URL: http://dx.doi.org/10.1039/C39930000337
Abstract
Coded amino acid L-lysine is utilized for the design of a chemical nuclease model wherein the α-amino carboxylate unit of the amino acid is used for the formation of the copper complex acting as the metal cleaving centre, and the ω-amino function of the molecule is exploited to carry the DNA recognition elements; models with duplex purines and quinazolines as the carrier ligands attached at the ω-amino end of the lysine–metal template are synthesized and demonstrated to effect the cleavage of double stranded DNA under physiological conditions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Soceity of Chemistry. |
| ID Code: | 97048 |
| Deposited On: | 22 Jan 2013 06:29 |
| Last Modified: | 22 Jan 2013 06:29 |
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