Jyothirmai, G. ; Mishra, Rakesh K. (1994) Differential influence of DNA supercoiling on in vivo strength of promoters varying in structure and organisation in E. coli FEBS Letters, 340 (3). pp. 189-192. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(94)80135-5
Abstract
DNA supercoiling is known to influence promoter activity in vitro and in vivo in a promoter-dependent manner in prokaryotes. In order to investigate how topology may influence promoter function, we have studied two kinds of promoter variants, (i) where only the spacer region is altered, and (ii) where the same promoter is tandemly repeated in either the same or opposite orientation. These promoters respond very differently to alterations in DNA supercoiling, suggesting that the overall structure of the promoter and its context contribute to the differential response to alterations in supercoiling in vivo.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Biochemical Societies. |
| Keywords: | Transcription; Promoter; DNA Supercoiling; Escherichia Coli |
| ID Code: | 97045 |
| Deposited On: | 22 Jan 2013 07:00 |
| Last Modified: | 22 Jan 2013 07:00 |
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