Mehrotra, Jyoti ; Misra, Krishna ; Mishra, Rakesh K. (1994) DNA Intercalation and photoinduced cleavage by 4-nitro(N-hexylamine)1,8-naphthalimide Nucleosides and Nucleotides, 13 (4). pp. 963-978. ISSN 0732-8311
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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1525777...
Related URL: http://dx.doi.org/10.1080/15257779408011870
Abstract
A novel intercalator, 4-nitro(N-hexylamine) 1,8-naphthalimide, was synthesised and its DNA binding and photoinduced DNA cleavage properties were studied. The DNA unwinding results show that it binds through intercalation. Absorption and fluorescence spectroscopy reveal the preference for A/T base pairs as compared to G/C base pairs for the binding. The intercalator produces photoinduced single strand scissions in double helical DNA.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa plc. |
| ID Code: | 97044 |
| Deposited On: | 22 Jan 2013 07:14 |
| Last Modified: | 22 Jan 2013 07:14 |
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