Sharma, Anindra ; Anand, Namrata ; Sharma, Rahul ; Chaturvedi, Upma ; Khanna, A. K. ; Bhatia, Gitika ; Tripathi, Rama P. (2012) Synthesis of 5-aryl-6-cinnamoyl-7-methyl-flavanones as novel antioxidants and antihyperlipidemics Journal of Enzyme Inhibition and Medicinal Chemistry, 27 (2). pp. 211-222. ISSN 1475-6366
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Official URL: http://informahealthcare.com/doi/abs/10.3109/14756...
Related URL: http://dx.doi.org/10.3109/14756366.2011.585134
Abstract
An economical and efficient one-pot synthesis of a series of novel 5-aryl-6-cinnamoyl-7-methyl-flavanones has been developed by simple refluxing of cinnamoyl chalcones with NaOAc in aqueous ethanol in quantitative yields. These flavanones were screened for their in vitro antioxidant and in vivo antidyslipidemic activities. Among 24 compounds screened, four compounds 28, 29, 30, and 48 showed significant antidyslipidemic activities. However, out of all the compounds, only compound 28 exhibited significant antioxidant activity and other compounds showed moderate antioxidant activities.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa plc. |
| Keywords: | Cholesterol Lowering Agents; Antidyslipidemic; Cinnamoyl Chalcones; Diacetyl Benzene; Sodium |
| ID Code: | 96993 |
| Deposited On: | 11 Feb 2013 06:38 |
| Last Modified: | 11 Feb 2013 06:38 |
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