Husain, Maroof ; Shukla, Rakesh ; Dikshit, Madhu ; Maheshwari, Pradeep K. ; Nag, Devika ; Srimal, Rikhab C. ; Seth, Prahlad K. ; Khanna, Vinay K. (2009) Altered platelet monoamine oxidase-B activity in Idiopathic Parkinson's disease Neurochemical Research, 34 (8). pp. 1427-1432. ISSN 0364-3190
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Official URL: http://www.springerlink.com/content/b32k71918587hj...
Related URL: http://dx.doi.org/10.1007/s11064-009-9929-4
Abstract
A case-control study was undertaken to investigate the status of platelet monoamine oxidase-B (MAO-B) activity in Indian cases of idiopathic Parkinson's disease. A significant increase in the activity of platelet MAO-B was observed in Parkinson's cases (n = 26) as compared to controls (n = 26). No significant change in the activity of the enzyme was observed while the data was analysed with respect to age, sex and duration of disease. A trend of decrease in platelet MAO-B activity was observed in Parkinson's cases with respect to stage although the change was not significant. No correlation in platelet MAO-B activity was observed with respect to age and sex in the control subjects. Parkinson's cases treated with L-DOPA and MAO-B inhibitor exhibited decreased platelet MAO-B activity as compared to drug naive cases and those treated with L-DOPA alone. Interestingly, Parkinson's cases treated with L-DOPA and amantadine also had lower platelet MAO-B activity as compared to drug naive cases and those treated with L-DOPA alone. Activity of platelet MAO-B in Parkinson's patients was increased in naive cases and those treated with L-DOPA alone or in combination with other drugs compared to controls. The results of the present study indicate that phenotypic activity of platelet MAO-B is high in Indian Parkinson's cases. Further, action mechanism of drugs used in the treatment of Parkinson's disease could be understood by assay of platelet MAO-B activity. It is an interesting observation and may be looked further in large number of cases.
Item Type: | Article |
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Source: | Copyright of this article belongs to Springer-Verlag. |
Keywords: | Idiopathic Parkinson'S Disease; Platelet; Monoamine Oxidase-B |
ID Code: | 9681 |
Deposited On: | 02 Nov 2010 11:05 |
Last Modified: | 09 Feb 2011 04:13 |
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