Nitric oxide-dependent blood-brain barrier permeability alteration in the rat brain

Shukla, A. ; Dikshit, M. ; Srimal, R. C. (1996) Nitric oxide-dependent blood-brain barrier permeability alteration in the rat brain Cellular and Molecular Life Sciences, 52 (2). pp. 136-140. ISSN 1420-682X

Full text not available from this repository.

Official URL: http://www.springerlink.com/content/j03304007535m8...

Related URL: http://dx.doi.org/10.1007/BF01923358

Abstract

The role of nitric oxide (NO), a well known vasodilator, in the regulation of blood-brain barrier (BBB) permeability is not clear. Therefore, the present study was planned to assess the role of NO-releasing compounds like sodium nitroprusside (SNP) and the active metabolite of molsidomine, SIN-1, as well as a precursor of NO, L-arginine, on this physiological barrier. The permeability was assessed by using several tracers. All three agents increased the permeability of BBB to the tracer. The increase in permeability caused by L-arginine was not blocked by N-nitro-L-arginine methyl ester (L-NAME). L-Arginine-treated brains did not show an elevation of nitrite content, thus ruling out the possibility of NO generation and its involvement in BBB permeability alteration. It is concluded that NO itself causes an increase in the permeability of BBB. However arginine-induced opening is not NO mediated.

Item Type:Article
Source:Copyright of this article belongs to Birkhauser-Verlag.
Keywords:Blood-Brain Barrier; Nitric Oxide; Arginine; Sodium Fluorescein; N-Nitro L-Arginine Methyl Ester
ID Code:9658
Deposited On:02 Nov 2010 11:16
Last Modified:30 May 2011 11:31

Repository Staff Only: item control page