Batra, S. ; Roy, A. K. ; Patra, A. ; Bhaduri, A. P. ; Surin, W. R. ; Raghavan, S. A. V. ; Sharma, P. ; Kapoor, K. ; Dikshit, M. (2004) Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents Bioorganic & Medicinal Chemistry, 12 (9). pp. 2059-2077. ISSN 0960-894X
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Official URL: http://dx.doi.org/10.1016/j.bmc.2004.02.023
Related URL: http://dx.doi.org/10.1016/j.bmc.2004.02.023
Abstract
The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Baylis-Hillman Reaction; Isoxazolecarbaldehyde; Isoxazole; Nucleophilic Substitution; Substituted Piperazine; Antithrombotic Activity; Platelet Aggregation |
| ID Code: | 9580 |
| Deposited On: | 02 Nov 2010 11:52 |
| Last Modified: | 30 May 2011 09:45 |
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