Levy, Abraham ; Manoharan, Periakaruppan T. ; Rifkind, Joseph M. ; Walker, James C. ; Haberle, Frederick C. ; Kumar, Narinder G. ; Glickson, Jerry D. ; Elgavish, Gabriel A. (1989) Mössbauer, EPR and NMR studies of the acid-induced reduction and changes in spin state of ferric bleomycin Biochimica et Biophysica Acta (BBA) - General Subjects, 991 (1). pp. 97-108. ISSN 0304-4165
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0304-4165(89)90034-2
Abstract
Iron-57 Mössbauer, electron paramagnetic resonance (EPR) and H-1 nuclear magnetic resonance (NMR) studies of iron-bleomycin complexes in the pH range from 1.0 to 6.0 are reported. Sequential protonation of the ligands produces a variety of high-spin and low-spin complexes of the metal. Of particular interest is the reversible equilibrium between Fe(III)- and oxygen-stable Fe(II)-bleomycin. Below pH 3.5 Fe(II) complexes form, with maximal reduction occurring at approximately pH 2. At still lower pH, Fe(III) complexes unassociated with bleomycin become dominant. The observed reduction in the absence of exogenous reducing agents suggests the possible involvement of intramolecular autoreduction in bleomycin-mediated DNA degradation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Bleomycin; Ion-Bleomycin Complex; Mössbauer; ESR; NMR |
| ID Code: | 95701 |
| Deposited On: | 20 Nov 2012 10:34 |
| Last Modified: | 20 Nov 2012 10:34 |
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