Dhingra, Sakshi ; Taneja, Neetu K. ; Tyagi, Jaya S. ; Kaur, Kohinoor (2012) DevR (DosR) binding peptide inhibits adaptation of Mycobacterium tuberculosis under hypoxia FEMS Microbiology Letters, 330 (1). pp. 66-71. ISSN 1574-6968
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...
Related URL: http://dx.doi.org/10.1111/j.1574-6968.2012.02534.x
Abstract
DevR is a key regulator of the dormancy response in Mycobacterium tuberculosis (M. tb). Using DevR as bait to screen a phage display library, a peptide, DevRS1, was obtained. DevRS1 inhibited DevR-regulated transcription and survival of nonreplicating tubercle bacilli in a hypoxia model of dormancy. DevRS1 peptide-mediated inhibition demonstrates the efficacy of intercepting DevR function to block hypoxic adaptation of M. tb.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | DevR; DosR; DevR Binding Peptide; Phage Display |
| ID Code: | 95572 |
| Deposited On: | 11 Feb 2013 10:06 |
| Last Modified: | 11 Feb 2013 10:06 |
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