Mishra, Jitendra Kumar ; Samanta, Krishnananda ; Jain, Manish ; Dikshit, Madhu ; Panda, Gautam (2010) Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: a new class of antithrombotic agents Bioorganic & Medicinal Chemistry Letters, 20 (1). pp. 244-247. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2009.10.126
Abstract
A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the position number 3. Further the effect of ring size has also been taken into account and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Amino Acids; Benzodiazepines; Benzoxazepines; Benzothiazepines; Benzoxazocine; Antithrombotic Activity |
| ID Code: | 9541 |
| Deposited On: | 02 Nov 2010 11:59 |
| Last Modified: | 09 Feb 2011 04:04 |
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