Serum IgM rheumatoid factor by enzyme-linked immunosorbent assay (ELISA) delineates a subset of patients with deforming joint disease in seronegative juvenile rheumatoid arthritis

Aggarwal, A. ; Dabadghao, S. ; Naik, S. ; Misra, R. (1994) Serum IgM rheumatoid factor by enzyme-linked immunosorbent assay (ELISA) delineates a subset of patients with deforming joint disease in seronegative juvenile rheumatoid arthritis Rheumatology International, 14 (4). pp. 135-138. ISSN 0172-8172

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Official URL: http://link.springer.com/article/10.1007%2FBF00579...

Related URL: http://dx.doi.org/10.1007/BF00579698

Abstract

Using human IgG as an antigen in an enzymelinked immunosorbent assay (ELISA), we looked for the presence of IgM rheumatoid factor (RF) in the sera of 74 children with juvenile rheumatoid arthritis (JRA). Nine children had RF detectable by both latex agglutination and ELISA. Forty-five percent (26 of 65) of the children who were seronegative by latex agglutination were found to be positive for IgM RF by ELISA. The prevalence of IgM RF was higher in patients with polyarticular onset disease (57.4%) than in those with pauciarticular onset (38.5%) or systemic onset (27.2%) disease. The prevalence of RF was higher in sera from patients with deforming joint disease than those without deformities (P<0.01).

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:JCA; Autoantibodies; Disease Severity
ID Code:95178
Deposited On:22 Oct 2012 07:14
Last Modified:22 Oct 2012 07:14

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