Compound heterozygosity of HLA-DR4 and DR1 antigens in Asian Indians increases the risk of extra-articular features in rheumatoid arthritis

Aggarwal, A. ; Dabadghao, S. ; Naik, S. ; Misra, R. ; Agrawal, S. (1995) Compound heterozygosity of HLA-DR4 and DR1 antigens in Asian Indians increases the risk of extra-articular features in rheumatoid arthritis British Journal of Rheumatology, 34 (1). pp. 41-44. ISSN 0263-7103

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Official URL: http://rheumatology.oxfordjournals.org/content/34/...

Related URL: http://dx.doi.org/10.1093/rheumatology/34.1.41

Abstract

The relationship of HLA-DR antigens in rheumatoid arthritis (RA) patients with the presence of rheumatoid factor (RF), extra-articular features, joint erosions, functional status and response to disease modifying anti-rheumatic drugs (DMARDs) was studied. Seventy-four patients with RA were serologically typed for class II antigens. Clinical features were recorded before starting DMARDs and during follow-up to assess response and side-effects. HLA-DR1 and DR4 antigens were present more frequently in patients with RA than in the general population. The presence of DR4 correlated with RF seropositivity (P < 0.001) while DR1 was associated with seronegativity (P < 0.02). Ten of the 11 patients with extra-articular features had DR1 and/or DR4. Patients with both DR4 and DR1 had a significantly higher frequency of extra-articular features compared with those with only one of these (P < 0.01). HLA-DR4 and DR1 had no relation with the presence of subcutaneous nodules, erosive changes, deformities, response to drugs and side-effects of DMARDs.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
Keywords:MHC-Disease Association; Disease Severity.
ID Code:95177
Deposited On:03 Mar 2013 07:19
Last Modified:03 Mar 2013 07:19

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