Nucleotides. Part XV. a synthesis of uridine-5′ pyrophosphate, a breakdown product of the coenzyme uridine-diphosphate-glucose

Abstract

Uridine.5’ pyrophosphate has been synthesized by condensing 2’:3’-iso-propylidene 5’-iodo-5’-deoxyuridine with silver tribenzyl pyrophosphate and subsequently removing the protecting groups. The product, isolated as its barium salt, is identical with the “uridine diphoshate” obtained as a break down product of the naturally occurring coenzyme UDPG. In course of the work described use has been made of the observation that lithium chloride removes two benzyl groups from fully esterified pyrophosphates.