Kumar, Arvind ; Aggarwal, Rakesh ; Naik, S. R. ; Saraswat, Vivek ; Ghoshal, Uday C. ; Naik, Sita (2004) Hepatitis E virus is responsible for decompensation of chronic liver disease in an endemic region Indian Journal of Gastroenterology, 23 (2). pp. 59-62. ISSN 0254-8860
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Official URL: http://www.indianjgastro.com/IJG_pdf/march2004/59-...
Abstract
Background: Hepatitis A virus infection in patients with previously stable chronic liver disease is associated with liver decompensation. Whether infection with hepatitis E virus (HEV) also does so is not known. Methods: We studied 32 patients with decompensated liver disease and definite evidence of underlying cirrhosis for evidence of recent HEV infection. Results: Of 32 patients, 14 (44%) had detectable IgM anti-HEV in their serum. In comparison, only 3 of 48 (6%) patients with stable cirrhosis and no recent decompensation had such antibodies (p<0.0001). Of the 14 patients with evidence of recent HEV infection, 11 had history of prodrome. The etiology of cirrhosis in these patients was: hepatitis B 6, hepatitis C 2, both hepatitis B and C 2, Wilson's disease 1, autoimmune 1 and cryptogenic 2. Two of these 14 patients died. Twelve patients survived, as compared to 9 of 18 patients without evidence of recent HEV infection (p<0.01). Conclusion: HEV infection is a frequent cause of decompensation in patients with liver cirrhosis in HEV-endemic regions.
Item Type: | Article |
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Source: | Copyright of this article belongs to Indian Society of Gastroenterology. |
Keywords: | Cirrhosis of Liver; Hepatitis E; Liver Failure; Superinfection |
ID Code: | 94901 |
Deposited On: | 16 Oct 2012 08:12 |
Last Modified: | 16 Oct 2012 08:12 |
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