Safety and efficacy of an indigenous human recombinant interferon alpha 2b (Shanferon) in patients with chronic hepatitis B

Chowdhury, Abhijit ; Shah, Samir ; Babu, Sethu ; Rai, Ramesh Roop ; Prasad, Mohan V. G. ; Rao, Raman ; Singh, Kavita ; Aggarwal, Rakesh (2005) Safety and efficacy of an indigenous human recombinant interferon alpha 2b (Shanferon) in patients with chronic hepatitis B Tropical Gastroenterology, 26 (2). pp. 70-72. ISSN 0250-636X

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Abstract

Interferon treatment is the established option for the treatment of patients with chronic hepatitis B without decompensated liver disease. However, such treatment is expensive. We report here our data of a multi-center, open-label trial of the use of an indigenously produced interferon in the treatment of chronic HBeAg-positive chronic hepatitis B. Adult patients with chronic HBeAg-positive hepatitis B with elevated serum transaminase activity and positive serum HBV DNA test were treated with 5 MU/day of an indigenously produced interferon (Shanferon; Shantha Biotechnics, Hyderabad, India) for 4 months, and were then followed up for 6 months. Of the 39 patients enrolled, 36 completed the treatment and 33 completed the post-treatment follow-up. Of the 33 patients who completed the study, end-of-treatment biochemical and virological responses were observed in 10 (30%) and 5 (15%) respectively. Sustained biochemical and virological responses were observed in 15 (45%) and 7 (21%), patients respectively. Adverse effects led to the discontinuation of treatment in only one patient. Our data suggest that safety and efficacy of the indigenously produced interferon were similar to those previously reported results with interferon from other sources.

Item Type:Article
Source:Copyright of this article belongs to Gastroenterology Research amp; Education Society and Indian Association of Surgical Gastroenterology.
ID Code:94894
Deposited On:16 Oct 2012 07:27
Last Modified:16 Oct 2012 07:27

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