Recurrent duodenal ulcer haemorrhage: a pharmacoeconomic comparison of various management strategies

Ghoshal, Uday Chand ; Aggarwal, Rakesh ; Baba, Chalamalasetty Sreenivasa (2003) Recurrent duodenal ulcer haemorrhage: a pharmacoeconomic comparison of various management strategies Expert Opinion on Pharmacotherapy, 4 (9). pp. 1593-1603. ISSN 1465-6566

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Official URL: http://dx.doi.org/10.1517/14656566.4.9.1593

Related URL: http://dx.doi.org/10.1517/14656566.4.9.1593

Abstract

Background: Duodenal ulcer (DU) bleeding has a 7 – 13% mortality rate and bleeding often recurs. Prevention of recurrence is, therefore, an important goal. Eradication of Helicobacter pylori or maintenance treatment with a proton pump inhibitor (PPI) may reduce recurrent DU bleeding. Economic comparison of these options is sparse.Methods: After the control of index bleeding with endotherapy and drugs, three strategies were evaluated: empirical treatment for possible H. pylori infection followed by a PPI for 2 months; test for H. pylori, eradication if positive, maintenance PPI if negative; maintenance PPI alone. Probability and direct cost data were obtained from a Medline search and Indian hospitals, respectively. Cost-minimisation, cost-utility, one- and two-way sensitivity analyses and threshold values were evaluated. Results: Treatment of H. pylori, particularly empirical, was the preferred strategy and dominated maintenance treatment with PPI. The test-and-treat strategy was better than the empirical treatment strategy only when the probabilities of H. pylori eradication, ulcer healing following eradication and of frequency of H. pylori infection in bleeding DU were less than 58, 73 and 58%, respectively.Conclusions: Eradication of H. pylori is preferred in preventing recurrent bleeding from DU.

Item Type:Article
Source:Copyright of this article belongs to Informa plc.
Keywords:Bleeding Peptic Ulcer; Cost-effectiveness; Gastrointestinal Haemorrhage; Helicobacter Pylori
ID Code:94614
Deposited On:19 Oct 2012 04:17
Last Modified:19 Oct 2012 04:17

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