Correlation of esophageal pH and motor abnormalities with endoscopic severity of reflux esophagitis

Somani, S. K. ; Ghoshal, U. C. ; Saraswat, V. A. ; Aggarwal, R. ; Misra, A. ; Krishnani, N. ; Naik, S. R. (2004) Correlation of esophageal pH and motor abnormalities with endoscopic severity of reflux esophagitis Diseases of the Esophagus, 17 (1). pp. 58-62. ISSN 1120-8694

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1442-...

Related URL: http://dx.doi.org/10.1111/j.1442-2050.2004.00374.x

Abstract

Motility abnormalities, common in gastroesophageal reflux disease, are likely to be related to endoscopic esophagitis. We studied pH and manometry parameters in relation to the severity of esophagitis. Forty-seven patients with symptomatic gastroesophageal reflux disease for > 3 months were evaluated by: (i) endoscopy (grading of esophagitis by Savary-Miller classification); (ii) mucosal biopsy; (iii) manometry; and (iv) 24-h pH-metry. We found Savary-Miller's grades of: 0 (9 patients out of 47), I (16/47), II (16/47), III (4/47), IV (2/47). Distal esophageal contraction amplitude was lower in severe (grade II to IV) as compared with mild (grade 0 and I) esophagitis (49 [7-182] versus 83 [27-196] mmHg [P = 0.001]). The length and pressure in the lower esophageal sphincter (LES), duration and velocity of contraction in the body, number of episodes of reflux and long-duration reflux, longest reflux, median pH, per cent of time with pH < 4 and DeMeester scores were not significantly different between the two groups. The area under pH 4 showed a negative correlation with LES pressure and amplitude of distal esophageal contractions. We conclude that higher endoscopic grades of esophagitis are associated with lower amplitude of contraction in distal esophagus. Lower LES pressure and distal esophageal contraction amplitude are associated with greater area under curve for pH below 4.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Esophageal Motility; Esophagitis; Gastroesophageal Reflux; pH; Pressure
ID Code:94610
Deposited On:19 Oct 2012 04:42
Last Modified:19 Oct 2012 04:42

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