Prajapati, Vijay Kumar ; Awasthi, Kalpna ; Yadav, Thakur Prasad ; Rai, Madhukar ; Srivastava, Onkar Nath ; Sundar, Shyam (2012) An oral formulation of amphotericin B attached to functionalized carbon nanotubes is an effective treatment for experimental visceral Leishmaniasis Journal of Infectious Diseases, 205 (2). pp. 333-336. ISSN 0022-1899
Full text not available from this repository.
Official URL: http://jid.oxfordjournals.org/content/205/2/333.ab...
Related URL: http://dx.doi.org/10.1093/infdis/jir735
Abstract
Amphotericin B (AmB), is a highly effective antileishmanial agent used as first-line treatment in different formulations in visceral leishmaniasis endemic areas of Bihar, India. However, parenteral infusion, prolonged hospitalization, and toxicity are major hurdles. Our previous work demonstrated the efficacy and stability of functionalized carbon nanotubes as a delivery mechanism for AmB. In this study, using the hamster model, we have shown that this novel formulation of AmB can be administered orally, resulting in 99% inhibition of parasite growth following a 5-day course at 15 mg/kg body weight.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to University of Chicago Press. |
ID Code: | 94425 |
Deposited On: | 15 Nov 2012 07:07 |
Last Modified: | 15 Nov 2012 07:07 |
Repository Staff Only: item control page