Synthesis & anticonvulsant activity of 7-Oxabicyclo[2.2.1]heptane derivatives. Part I. N-Alkyl, N-Aryl & N-Heteroaryl derivatives of 3,6-Epoxyhexahydrophthalimide

Joshi, Balawant S. ; David, Joy ; Gawad, Dilip H. (1983) Synthesis & anticonvulsant activity of 7-Oxabicyclo[2.2.1]heptane derivatives. Part I. N-Alkyl, N-Aryl & N-Heteroaryl derivatives of 3,6-Epoxyhexahydrophthalimide Indian Journal of Chemistry, 22 (2). pp. 131-135. ISSN 0019-5103

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Abstract

A series (sixty one) of N-substituted 3,6-epoxyhexahydrophthalimides have been prepared by the condensation of the appropriately substituted alkyl, aryl and heteroarylamines with exo-cis-3,6-epoxyhexahydrophthalic anhydride (2). Some of the compounds exhibit moderate anticonvulsant activity in electroshock, metrazol, strychnine and picrotoxin induced convulsions.

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