Gupta Roy, B. ; Datta, A. (1987) A calmodulin inhibitor blocks morphogenesis in Candida albicans FEMS Microbiology Letters, 41 (3). pp. 327-329. ISSN 0378-1097
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/037810...
Related URL: http://dx.doi.org/10.1111/j.1574-6968.1987.tb02221.x
Abstract
A calmodulin inhibitor, trifluoperazine (TFP), can block yeast-to-germ-tube morphogenesis of Candida albicans induced by N-acetyl-d-glucosamine at 37°C. Furthermore, the ionophore A23187 can also block germ tube formation, which can be reversed by Ca2+. This indicates the possible involvement of calcium and calmodulin in morphogenesis of C. albicans. During germ tube formation, there is a progressive increase in the rate of protein phosphorylation, which is completely absent in non-germinating cells (yeast form). Trifluoperazine can also inhibit this phosphorylation indicating that protein phosphorylation may also be involved in this process.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Microbiological Societies. |
| Keywords: | Candida Albicans; Morphogenesis; Trifluoperazine |
| ID Code: | 9351 |
| Deposited On: | 02 Nov 2010 12:23 |
| Last Modified: | 28 May 2011 10:14 |
Repository Staff Only: item control page
