Govindachari, T. R. ; Nagarajan, K. ; Natarajan, S. ; Pai, B. R. (1971) Studies in protoberberine alkaloids: Part IV. Synthesis of 13-Methyl-Ψ-coptisine Indian Journal of Chemistry, 9 . pp. 1313-1315. ISSN 0019-5103
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Abstract
Tetrahydro-13-methyl-y-coptisines (V) (m.p. 195°) and (VI) (m.p. 131°) have been synthesized from l-(α-methyl-3,4-methylenedioxybenzyl)-l,2,3,4-tetrahydro-6,7-methylenedioxyiso-quinoline (IV) by treating it with formaldehyde and hydrochloric acid. The products obtained as a mixture have been separated by column chromatography over silica using chloroform for eluting the column. Mercuric acetate oxidation of V-afforded 13-methyl-Ψ-coptisine (VII). Comparison of the melting points of the iodides and chlorides of VII and worenine suggests that worenine may be 13-methyl-Ψ-coptisine.
Item Type: | Article |
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Source: | Copyright of this article belongs to National Institute of Science Communication and Information Resources. |
ID Code: | 93472 |
Deposited On: | 19 Jun 2012 07:21 |
Last Modified: | 19 May 2016 06:33 |
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