Sidhu, G. S. ; Dhaunsi, G. S. ; Garg, U. C. ; Bhatnagar, R. (1986) Renal nutrients uptake and brush border membrane enzymes in cholesterol fed guinea pigs Biochemical Medicine and Metabolic Biology, 36 (2). pp. 175-189. ISSN 0885-4505
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0885-4505(86)90122-2
Abstract
The effect of dietary cholesterol load on the reabsorption of nutrients and the enzyme and chemical characteristics of renalbrush-bordermembrane (BBM) was evaluated in guineapigs. The transport of d-glucose and amino acids into the renal BBM vesicles of experimental animals was significantly (P < 0.001) decreased. Vmax of leucine aminopeptidase decreased without alteration in Km; however, both the Km and Vmax of alkaline phosphatase and maltase decreased in renalmembrane in response to cholesterol load. The alterations in the chemical architecture of the membrane could possibly be responsible for the observed aberrations in the kidneys of cholesterol-fed animals.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this aricle belongs to Elsevier Science. |
| ID Code: | 93463 |
| Deposited On: | 21 Jun 2012 05:56 |
| Last Modified: | 21 Jun 2012 05:56 |
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