Dhaunsi, G. S. ; Aulakh, B. S. ; Gupta, N. M. ; Majumdar, S. ; Chakravarti, R. N. (1988) Towards the mechanism of protection against indomethacin induced gastro-intestinal ulceration by naloxone Biochemistry International, 16 (3). pp. 511-519. ISSN 0158-5231
Full text not available from this repository.
Abstract
Activities of lysosomal hydrolases have been evaluated in relation to indomethacin and naloxone, using purified lysosomal fractions from rat intestinal mucosa. Indomethacin treatment significantly decreased (p less than 0.001) lysosomal enzyme activities in purified lysosomes, while an increase in the activities was observed in intestinal homogenates. However, indomethacin could not affect lysosomal system in animals pretreated with naloxone, thereby establishing that naloxone neutralises the effect of indomethacin.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to International Union of Biochemistry and Molecular Biology. |
| ID Code: | 93460 |
| Deposited On: | 25 Jul 2012 09:01 |
| Last Modified: | 25 Jul 2012 09:01 |
Repository Staff Only: item control page
