Paranjape, Vijay ; Datta, Asis (1991) Overexpression of the actin gene is associated with the morphogenesis of Candida albicans Biochemical and Biophysical Research Communications, 179 (1). pp. 423-427. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(91)91387-R
Abstract
A progressive increase in the synthesis of actin mRNA was observed by Northern blot analysis, when cells were induced to form germ tubes at 37°C by N-acetyl-D-glucosamine. Presence of trifluoperazine, a calmodulin inhibitor, or incubation of cells at 25°C, or by replacing N-acetyl-D-glucosamine with glucose which inhibited germ tube formation lowered this synthesis. Furthermore, in vitro translation of total RNA revealed an increase in the synthesis of actin (45 kDa) during germ tube formation. These results suggest for the first time that the expression of actin gene is regulated during morphogenesis of C. albicans.
| Item Type: | Article |
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| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 9332 |
| Deposited On: | 02 Nov 2010 12:28 |
| Last Modified: | 07 Feb 2011 09:43 |
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