Nagarajan, K. (1997) Quino[8,1-bc][1,4]benzooxazepines- HIV-1 reverse transcriptase inhibitors Journal of the Indian Chemical Society, 74 . pp. 831-833. ISSN 0019-4522
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Abstract
A series of quinobenzoxazepinones showed activity against the reverse transcriptase of IIIV-1. The most potent one was 13 with an amino and methyl substitution. Active compounds 5,12 and 13 inhibited both AZT-sensiliveand AZT- resistant strains of HIV-1 but were inactive against 'pyridone-resistant' HIV-1 and HIV-2. The tricyclic drbenzoxazepine derivative 23 also showed activity against HIV-1 RT.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Indian Chemical Society. |
| ID Code: | 93197 |
| Deposited On: | 13 Jun 2012 10:32 |
| Last Modified: | 19 May 2016 06:20 |
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