Maithreye, R. ; Suguna, C. ; Sinha, Somdatta (2011) Collective dynamics of multicellular systems Pramana - Journal of Physics, 77 (5). pp. 843-853. ISSN 0304-4289
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Official URL: http://www.ias.ac.in/pramana/v77/p843/fulltext.pdf
Abstract
We have studied the collective behaviour of a one-dimensional ring of cells for conditions when the individual uncoupled cells show stable, bistable and oscillatory dynamics. We show that the global dynamics of this model multicellular system depends on the system size, coupling strength and the intrinsic dynamics of the cells. The intrinsic variability in dynamics of the constituent cells are suppressed to stable dynamics, or modified to intermittency under different conditions. This simple model study reveals that cell–cell communication, system size and intrinsic cellular dynamics can lead to evolution of collective dynamics in structured multicellular biological systems that is significantly different from its constituent single-cell behaviour.
Item Type: | Article |
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Source: | Copyright of this article belongs to Indian Academy of Sciences. |
Keywords: | Nonlinear Regulation; Bistable; Oscillations; Biochemical Pathway; Synchronization; Multicell system. |
ID Code: | 93066 |
Deposited On: | 08 Jun 2012 10:35 |
Last Modified: | 19 May 2016 06:14 |
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