Hypoglycaemic effect of combination of glibenclamide and phenformin - an experimental study

Abstract

Clinical studies have shown that a combination of glybenclamide and phenformin is more useful in control of diabetes than either drug used alone. This pharmacological study shows that phenformin had no significant hypoglycaemic effect in normal dogs. However, when phenformin is combined with glybenclamide, the effect was more marked and quicker than with glybenclamide alone. The different sites of action of the drugs may be responsible for this interesting response.