Mohan, V. ; Snehalatha, C. ; Ramachandran, A. ; Viswanathan, M. (1986) Abnormalities in insulin secretion in healthy offspring of Indian patients with maturity-onset diabetes of the young Diabetes Care, 9 (1). pp. 53-56. ISSN 0149-5992
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Official URL: http://care.diabetesjournals.org/content/9/1/53.fu...
Related URL: http://dx.doi.org/10.2337/diacare.9.1.53
Abstract
Serum C-peptide (CP) and immunoreactive insulin (IRI) responses were studied in 47 euglycemic offspring of patients with maturity-onset diabetes of the young (MODY). Mean IRI responses were not significantly different in nonobese offspring of MODY patients (O-MODY) but they were lower in obese O-MODY than in respective controls. Mean CP responses were low in both groups, the change being more pronounced in obese O-MODY. These findings indicate that alterations of secretion and metabolism of insulin can be detected even before glucose intolerance is seen in O-MODY.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Diabetes Association. |
| ID Code: | 92443 |
| Deposited On: | 01 Jun 2012 11:55 |
| Last Modified: | 01 Jun 2012 11:55 |
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