Sathiagana Seelan, R. ; Padmanaban, Govindarajan (1988) A processed pseudogene with an intact coding sequence for rat liver cytochrome c oxidase subunit VIc Gene, 67 (1). pp. 125-130. ISSN 0378-1119
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0378-1119(88)90015-7
Abstract
The biogenesis of eukaryotic cytochrome c oxidase involves the coordinate expression of nuclear and mitochondrial genes. Very little information is available on the gene structure of nuclear-coded cytochrome c oxidase subunits in mammalian systems. We report here the isolation and complete nucleotide sequence determination of a processed pseudogene for cytochrome c oxidase subunit VIc from rat liver. The pseudogene lacks introns and the coding region is intact with no deleterious lesions; however, there are 7 amino acid (aa) differences when compared to the sequence derived from cDNA clones. The pseudogene has the potential to code for a protein of 76 aa, containing a putative 3 aa N-terminal presequence when compared to the mature bovine heart VIc subunit. Potential regulatory regions, including a TATA box, are present in the 5'-flanking region.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Recombinant DNA; Nucleotide Sequencing; Gene Family; Presequence; 5'-flanking Sequence; Myopathies |
| ID Code: | 91971 |
| Deposited On: | 25 May 2012 13:56 |
| Last Modified: | 25 May 2012 13:56 |
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