Uma, K. ; Balaram, P. (1989) Peptide design: an analysis of studies using α-aminoisobutyric acid (Aib) and Z α β -dehydrophenylalanine (ΔZ-Phe) Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry, 28 . pp. 705-710. ISSN 0376-4699
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Abstract
The utility of α-aminoisobutyryl (Aib) residues in peptide conformational design is examined in the light of available data on the stereochemistry of Aib containing peptides. The role of Aib residues in helix nucleation is exemplified by several recent crystal structures. An analysis of available stereochemical data on α.β-dehydrophenylalanine (Δz-Phe) containing peptides is presented to assess the potential of this residue in restricting peptide conformations. The present analysis is intended to correct misleading impressions presented in a recent paper in this journal [Singh T P & Chauhan V S, Indian J Chem, 27B( 1988) 877].
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Institute of Science Communication and Information Resources. |
| ID Code: | 91387 |
| Deposited On: | 21 May 2012 08:30 |
| Last Modified: | 21 May 2012 08:30 |
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