Nagarajan, K. ; Hendi, S. B. ; Goud, A. N. ; Sen, H. G. ; Deb, B. N. (1986) Quest for anthelminitic agents. Part II. Benzothiazole and benzotriazole carbamates and 2-benzazolyl vinyl ketones Indian Journal of Pharmaceutical Sciences, 48 (4). pp. 85-88. ISSN 0250-474X
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Official URL: http://www.ijpsonline.com/article.asp?issn=0250-47...
Abstract
Several benzthiazole carbamate analouges 12-17 and 21 of anthelminitic benzimidazole carbamates like mebendazole (1) and fenbendazole(3) are synthesised from the corresponding 2-aminobenzthiazoles. 1,2-Diamino-5,6,7,8-tetrahydronapthalene asffords through the aminonaphthimidazole 23, the carbamate 24 which is a cyclised version of parbendazole (4). 3,4-Diaminobenzophenone upon diazotisation gives the benzotriazole 25 and thence the ester 26. 2-Acetylbenzimidazole (27) and 2-acetylbenzthiazole (28) are condensed with aldehydes to give 2-benzazolyl vinyl ketones 29-34. All the products are found to be inactive in curing hamsters of N. americanus infection.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Medknow Publications. |
| ID Code: | 90760 |
| Deposited On: | 14 May 2012 04:43 |
| Last Modified: | 14 May 2012 04:43 |
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