Maller, R. K. ; Nagarajan, K. ; Zoebeli, H. (1985) Synthesis of 14C-labelled 1-(3,5-bis-trifluoromethyl)-phenyl-4-methyl thiosemicarbazide, C 2696-GO Journal of Labelled Compounds and Radiopharmaceuticals, 22 (3). pp. 217-227. ISSN 0362-4803
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jlcr.25...
Related URL: http://dx.doi.org/10.1002/jlcr.2580220303
Abstract
For pharmacokinetic and metabolism studies in experimental animals C 2696-Go was labelled initially with 14C on the thiocarbonyl carbon of the thiosemicarbazide moiety of the molecule, having a specific activity of 3.14 µCi/mg, in a radiochemical yield of 43%, based on the starting potassium [14C]thiocyanate. C 2696-Go alternatively labelled with 14C on one of the trifluoromethyl groups, having a specific activity of 3.6 µCi/mg was also synthesized in an overall radiochemical yield of 5.1%, starting from Ba[14C]O3.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | C 2696-Go Carbon-14; Antifertility Agent; Antiimplantation Activity; Synthesis |
| ID Code: | 90755 |
| Deposited On: | 14 May 2012 04:42 |
| Last Modified: | 14 May 2012 04:42 |
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