Chaturvedi, U. C. ; Shukla, M. I. ; Mathur, K. R. ; Mathur, A. (1981) Dengue virus-induced cytotoxic factor suppresses immune response of mice to sheep erythrocytes Immunology, 43 (2). pp. 311-316. ISSN 0019-2805
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Official URL: http://www.interscience.wiley.com/jpages/0019-2805...
Abstract
The present study was undertaken to investigate if the suppressed cell-mediated immune responses observed in dengue type 2 virus (DV)-infected mice could be due to the cytotoxic factor (CF) produced in the spleens of DV-infected mice. We have observed that CF given intravenously (i.v.) kills splenic cells and reduces the total cells in the spleen. Mice treated with CF have a significantly depressed immune response to sheep erythrocytes, viz. delayed-type-hypersensitivity as measured by footpad swelling reaction at 24 hr; Jerne's antibody plaque-forming cells in the spleen; and migration inhibition of spleen cells in presence of antigen. These findings are similar to those seen earlier in DV-infected mice.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| ID Code: | 90681 |
| Deposited On: | 12 May 2012 05:00 |
| Last Modified: | 25 Jun 2012 10:20 |
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