Gulati, L. ; Chaturvedi, U. C. ; Mathur, A. (1986) Production of dengue virus-induced macrophage cytotoxin in vivo British Journal of Experimental Pathology, 67 (2). pp. 269-277. ISSN 0007-1021
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Abstract
We have observed that dengue virus-induced cytotoxic factor (CF) induces peritoneal and splenic macrophages in vitro to produce a cytotoxin (CF2). This study demonstrates also production of CF2 in vivo in DV-infected mice and following inoculation with CF. The cell-type responsible for CF2 production in vivo is the macrophage (M phi) as M phi-depleted mice failed to produce CF2. CF2 activity could not be observed in the serum or peritoneal fluid though it is produced in peritoneal M phi. Once stimulated, CF2 is present for 4 h in M phi. M phi can be restimulated to produce CF2 only after a refractory period of 48 h.
Item Type: | Article |
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Source: | Copyright of this article belongs to Lewis, London. |
ID Code: | 90652 |
Deposited On: | 14 May 2012 05:40 |
Last Modified: | 25 Jun 2012 10:29 |
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