Induction of secondary immune response by reactivated Japanese encephalitis virus in latently infected mice

Mathur, A. ; Kulshreshtha, R. ; Chaturvedi, U. C. (1987) Induction of secondary immune response by reactivated Japanese encephalitis virus in latently infected mice Immunology, 60 (4). pp. 481-484. ISSN 0019-2805

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Official URL: http://www.interscience.wiley.com/jpages/0019-2805...

Abstract

Development of secondary immune response has been studied following reactivation of latent Japanese encephalitis virus (JEV) infection in mice. The virus could be reactivated in 43% of the latently infected mice at 27 weeks p.i. by treatment with cyclophosphamide. The reactivated virus induced delayed-type hypersensitivity (DTH) and leucocyte migration inhibition (LMI) responses in mice, with peak activity on Day 5 post-reactivation (p.r.). The DTH persisted at low levels for long periods. Humoral immunity measured by haemagglutination-inhibiting antibody showed a four-fold rise in antibody titres. DTH was transferable by immune spleen cells for 5 days p.r. only. It is, therefore, concluded that JEV reactivation generates a quick and short-lived secondary immune response.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:90646
Deposited On:11 May 2012 07:21
Last Modified:25 Jun 2012 10:31

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