Dhawan, R. ; Mukerjee, R. ; Chaturvedi, U. C. ; Khare, S. D. (1995) Flow cytometric analysis of T4:T8 splenic cell during dengue virus infection of mice Indian Journal of Experimental Biology, 33 (11). pp. 816-823. ISSN 0019-5189
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Abstract
The present study was undertaken to investigate the effect of dengue type 2 virus (DV) and DV-induced cytokines (CF and CF2) on T lymphocyte subpopulations of spleen by flow cytometry. Following DV-ic inoculation in mice the percent number of CD4+ and CD8+ lymphocytes in the spleen was reduced, the peak reduction in both was observed on the 6th day post-inoculation (p.i.). Intravenous inoculation of CF or CF2 in mice also decreased the percent number of CD4+ as well as CD8+ T lymphocytes subpopulation in the spleen, the maximum reduction being observed at 1 and 2 hr, respectively. The reduction in T lymphocyte subpopulation by CF and CF2 was found to be dose dependent. Thus, the alterations of T lymphocyte subpopulations during DV infection are mediated via cytokines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Institute of Science Communication and Information Resources. |
| ID Code: | 90527 |
| Deposited On: | 10 May 2012 10:36 |
| Last Modified: | 10 May 2012 10:36 |
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